It is the long history of humankind (and animal kind, too) those who learned to collaborate and improvise most effectively have prevailed.” 


Our lab concentrates on solving problems for the most important biological problems, as such we build extensive collaborations with other labs:

 

Prof Sir David Klenerman, FRS (Chemistry, Cambridge). Single-molecule light sheet microscopy.

Prof Simon Davis (Weatherall Institute for Molecular Medicine, Oxford). Molecular Origin of Human Adaptive immunity.

Prof Andres Floto (Laboratory of Molecule Biology, LMB, Cambridge). Single-molecule K-Ras signalling in Cancer.

Dr David Gershlick (Cambridge Institute for Medical Research, CIMR, Cambridge). Golgi-mediated protein sorting. 

Prof Tom Snaddon (Chemistry, Indiana, USA). Novel fluorophore development.

Prof Nicholas Wood (Institute for Neurology, UCL). New tools for visualising oligomer in Parkinson’s Disease. 

Prof Nick Evans (Bioengineering, Southampton). Single-molecule Wnt3a dynamics. 

Dr Kevin O’Holleran (Cambridge Advanced Imaging Centre, Cambridge). 3D Super-Resolution Imaging development.

Dr Amalio Fernandez-Pacheco (Physics, Glasgow). 3D nanostructures for biological imaging.

Prof Sonia Gandhi (The Crick Institute, London). Structurally specific immunoprecipitation in human spinal fluid.

 

Patch deconvolution for Fourier light-field microscopy
B Fu, C Jones, D Heraghty, S Yang, C O’Brien-Ball, V Junghans, H Yang, TPJ Knowles, L Weiss, R Fernandes, S Lee
(2025)
Volumetric single-molecule tracking inside subcellular structures
S Daly, JE Chambers, C Jones, B Fu, JD Manton, JS Beckwith, SJ Marciniak, DC Gershlick, SF Lee
(2025)
Advanced image processing methods for 3D high-throughput microscopy
B Fu
(2025)
The Origin of Single-Molecule Sensitivity in Label-Free Solution-Phase Optical Microcavity Detection
CA Saavedra Salazar, D Sole-Barber, S Wan, JK Rasch, M Reitz, B Cullinane, N Asgari, L-M Needham, J Yuen-Zhou, RH Goldsmith
ACS nano
(2025)
19
3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O Holleran, SGN Grant, MH Horrocks, SF Lee
ACS Chemical Neuroscience
(2024)
16