It is the long history of humankind (and animal kind, too) those who learned to collaborate and improvise most effectively have prevailed.” 


Our lab concentrates on solving problems for the most important biological problems, as such we build extensive collaborations with other labs:

 

Prof Sir David Klenerman, FRS (Chemistry, Cambridge). Single-molecule light sheet microscopy.

Prof Simon Davis (Weatherall Institute for Molecular Medicine, Oxford). Molecular Origin of Human Adaptive immunity.

Prof Andres Floto (Laboratory of Molecule Biology, LMB, Cambridge). Single-molecule K-Ras signalling in Cancer.

Dr David Gershlick (Cambridge Institute for Medical Research, CIMR, Cambridge). Golgi-mediated protein sorting. 

Prof Tom Snaddon (Chemistry, Indiana, USA). Novel fluorophore development.

Prof Nicholas Wood (Institute for Neurology, UCL). New tools for visualising oligomer in Parkinson’s Disease. 

Prof Nick Evans (Bioengineering, Southampton). Single-molecule Wnt3a dynamics. 

Dr Kevin O’Holleran (Cambridge Advanced Imaging Centre, Cambridge). 3D Super-Resolution Imaging development.

Dr Amalio Fernandez-Pacheco (Physics, Glasgow). 3D nanostructures for biological imaging.

Prof Sonia Gandhi (The Crick Institute, London). Structurally specific immunoprecipitation in human spinal fluid.

 

Volumetric Single-Molecule Tracking Inside Subcellular Structures.
S Daly, JE Chambers, C Jones, B Fu, JD Manton, JS Beckwith, SJ Marciniak, DC Gershlick, SF Lee
Small
(2026)
Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells
GG Agsu, Y Cao, D Jain, SE Strawbridge, S Daly, Z Zhang, A Wurmser, K Bowers, IO De Almeida, G Nikolenyi, S Berger, M Jonaitis, K Guma’a, T Pauzaite, S Maretvadakethope, L Bates, JA Nathan, BD Hendrich, R Perez-Carrasco, KJ Chalut, D Klenerman, TE Boroviak, SF Lee, D Holcman, S Basu
(2025)
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal.
MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, E Fertan, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl
(2025)
α-Synuclein driven cell susceptibility in Parkinson’s disease
S Lee, J Breiter, J Beckwith, E Brock, J Lachica, C Toomey, B Fu, M Ryten, L Weiss, N Wood, S Gandhi, M Vendruscolo
(2025)
Large-scale visualization of α-synuclein oligomers in Parkinson's disease brain tissue.
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, JS Beckwith, R Tian, EE Brock, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, R Popovic, J Evans, Y Goh, B Kurt, L Senicar, M Edmonds, T Bartels, N Bengoa-Vergniory, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
Nature biomedical engineering
(2025)