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  • Currently displaying 1 - 20 of 239 publications
Author(s)
Publication title
Journal Name
Publication year
Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal
MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, E Fertan, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl
(2025)
(doi: 10.1101/2025.09.08.674880)
α-Synuclein driven cell susceptibility in Parkinson’s disease
S Lee, J Breiter, J Beckwith, E Brock, J Lachica, C Toomey, B Fu, M Ryten, L Weiss, N Wood, S Gandhi, M Vendruscolo
(2025)
(doi: 10.21203/rs.3.rs-7375981/v1)
Large-scale visualization of α-synuclein oligomers in Parkinson’s disease brain tissue
R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, JS Beckwith, R Tian, EE Brock, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, R Popovic, J Evans, Y Goh, B Kurt, L Senicar, M Edmonds, T Bartels, N Bengoa-Vergniory, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee
Nature Biomedical Engineering
(2025)
(doi: 10.1038/s41551-025-01496-4)
Nano-org, a functional resource for single-molecule localisation microscopy data
S Shirgill, DJ Nieves, JA Pike, MA Ahmed, H Abbott, MHH Baragilly, K Savoye, JD Worboys, KS Hazime, E Bruggeman, A Garcia, DJ Williamson, P Rubin-Delanchy, R Peters, DM Davis, R Henriques, SF Lee, DM Owen
Nature communications
(2025)
16
(doi: 10.1038/s41467-025-63674-x)
Species-specific surface dwell times and accumulation of microbes investigated by holographic microscopy.
EE Brock, SA Matthews, EJ Cohen, S Nakamura, LG Wilson
Philos Trans A Math Phys Eng Sci
(2025)
383
(doi: 10.1098/rsta.2024.0265)
Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease
JR Evans, M Grant-Peters, JS Beckwith, CE Toomey, R Popovic, JC Breiter, JW Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, EE Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, RS Saleeb, H Lucas-Clarke, A Penverne, K D’Sa, CW Pang, MH Horrocks, M Vendruscolo, N Wood, SF Lee, M Ryten, S Gandhi
(2025)
(doi: 10.1101/2025.08.25.671921)
α-Synuclein driven cell susceptibility in Parkinson’s disease
JC Breiter, JS Beckwith, EE Brock, J Lachica, CE Toomey, B Fu, M Ryten, LE Weiss, NW Wood, S Gandhi, M Vendruscolo, SF Lee
(2025)
(doi: 10.1101/2025.08.19.670819)
DHPSFU: a Fiji plugin for fast and accurate double helix-PSF 3D single-molecule localisation microscopy
Z Zhang, A Ochirova, S Liu, AD Herbert, Y Wu, W Boucher, SF Lee, ED Laue, D Klenerman, A Ponjavic
Scientific Reports
(2025)
15
(doi: 10.1038/s41598-025-15623-3)
Patch deconvolution for Fourier light-field microscopy
B Fu, CL Jones, D Heraghty, S Yang, C O’Brien-Ball, V Junghans, H Yang, TPJ Knowles, LE Weiss, RA Fernandes, SF Lee
(2025)
(doi: 10.1101/2025.06.13.659385)
Volumetric single-molecule tracking inside subcellular structures
S Daly, JE Chambers, C Jones, B Fu, JD Manton, JS Beckwith, SJ Marciniak, DC Gershlick, SF Lee
(2025)
(doi: 10.1101/2025.06.09.658280)
Advanced image processing methods for 3D high-throughput microscopy
B Fu
(2025)
(doi: 10.17863/CAM.118852)
The Origin of Single-Molecule Sensitivity in Label-Free Solution-Phase Optical Microcavity Detection.
CA Saavedra Salazar, D Sole-Barber, S Wan, JK Rasch, M Reitz, B Cullinane, N Asgari, L-M Needham, J Yuen-Zhou, RH Goldsmith
ACS nano
(2025)
19
(doi: 10.1021/acsnano.4c16276)
3D Super-Resolution Imaging of PSD95 Reveals an Abundance of Diffuse Protein Supercomplexes in the Mouse Brain.
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O Holleran, SGN Grant, MH Horrocks, SF Lee
ACS chemical neuroscience
(2024)
16
(doi: 10.1021/acschemneuro.4c00684)
Vortex light field microscopy: 3D spectral single-molecule imaging with a twist
B Zhang, S Daly, C Zhu, MO Lenz, LE Weiss, L-M Needham, R Peters, SF Lee, K O’Holleran
Optica
(2024)
11
(doi: 10.1364/optica.534148)
3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O’Holleran, SGN Grant, MH Horrocks, SF Lee
(2024)
(doi: 10.1101/2024.10.14.617231)
POLCAM: instant molecular orientation microscopy for the life sciences.
E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, AS Klymchenko, SJ Davis, EK Paluch, D Klenerman, MD Lew, K O'Holleran, SF Lee
Nature Methods
(2024)
21
(doi: 10.1038/s41592-024-02382-8)
Evolution of a large periplasmic disk in Campylobacterota flagella enables both efficient motility and autoagglutination
EJ Cohen, T Drobnič, DA Ribardo, A Yoshioka, T Umrekar, X Guo, J-J Fernandez, EE Brock, L Wilson, D Nakane, DR Hendrixson, M Beeby
Developmental Cell
(2024)
59
(doi: 10.1016/j.devcel.2024.09.008)
Single-Molecule Sensitivity in Hot Microcavities in the Unstable Regime
CA Saavedra Salazar, D Sole-Barber, N Asgari, B Cullinane, L-M Needham, J Rasch, M Reitz, S Wan, J Yuen-Zhou, R Goldsmith
(2024)
(doi: 10.26434/chemrxiv-2024-xgtxg)
Single-molecule digital sizing of proteins in solution.
G Krainer, RPB Jacquat, MM Schneider, TJ Welsh, J Fan, QAE Peter, EA Andrzejewska, G Šneiderienė, MA Czekalska, H Ausserwoeger, L Chai, WE Arter, KL Saar, TW Herling, TM Franzmann, V Kosmoliaptsis, S Alberti, FU Hartl, SF Lee, TPJ Knowles
Nat Commun
(2024)
15
(doi: 10.1038/s41467-024-50825-9)
Vortex light field microscopy: 3D spectral single-molecule imaging with a twist
B Zhang, S Daly, C Zhu, MO Lenz, LE Weiss, L-M Needham, R Peters, SF Lee, K O’Holleran
(2024)
(doi: 10.1101/2024.07.18.604091)
Yusuf Hamied Department of Chemistry
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enquiries@ch.cam.ac.uk
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