(they/them)

I am a chemist/biophysicist based jointly between the Gershlick lab (Cambridge Institute for Medical Research) and the Lee Lab (Department of Chemistry) developing and applying single molecule microscopy techniques to understand the physical chemistry underpinning protein sorting in the Golgi apparatus. 

I obtained my PhD in chemistry from Cambridge in 2024 where I developed new three-dimensional single molecule microscopy tools to capture molecular insights into a range of biological questions (adaptive immunity, cellular cytoskeletal structures, and proteins trafficking). I received my MChem from the University of York in 2020, completing my master's thesis under the supervision of Dr Martin Cockett in spectroscopy. In particular, I used Resonance Enahnced Multiphoton Ionisation (REMPI) Spectroscopy and excited state electronic structure calculations to probe the weak interactions between biologically relevent molecules.

I also co-founded the Cambridge Queer in Chemistry Network (QiCN) that aims to provide a space within the department for staff and students to connect, socialise and celebrate with other queer chemists.

Publications

3D Super-Resolution Imaging of PSD95 Reveals an Abundance of Diffuse Protein Supercomplexes in the Mouse Brain
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O Holleran, SGN Grant, MH Horrocks, SF Lee
ACS Chemical Neuroscience
(2024)
16
Vortex light field microscopy: 3D spectral single-molecule imaging with a twist
B Zhang, S Daly, C Zhu, MO Lenz, LE Weiss, L-M Needham, R Peters, SF Lee, K O’Holleran
Optica
(2024)
11
3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain
S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O’Holleran, SGN Grant, MH Horrocks, SF Lee
(2024)
POLCAM: instant molecular orientation microscopy for the life sciences.
E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, AS Klymchenko, SJ Davis, EK Paluch, D Klenerman, MD Lew, K O'Holleran, SF Lee
Nature Methods
(2024)
21
Vortex light field microscopy: 3D spectral single-molecule imaging with a twist
B Zhang, S Daly, C Zhu, MO Lenz, LE Weiss, L-M Needham, R Peters, SF Lee, K O’Holleran
(2024)
Advances in volumetric super-resolution microscopy and single-particle tracking
S Daly
(2024)
High-density volumetric super-resolution microscopy
S Daly, J Ferreira Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O’Holleran, SF Lee
Nature Communications
(2024)
15
High-density volumetric super-resolution microscopy
S Daly, JF Fernandes, E Bruggeman, A Handa, R Peters, S Benaissa, B Zhang, JS Beckwith, EW Sanders, RR Sims, D Klenerman, SJ Davis, K O’Holleran, SF Lee
(2023)
POLCAM: Instant molecular orientation microscopy for the life sciences
E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, AS Klymchenko, SJ Davis, EK Paluch, D Klenerman, MD Lew, K O’Holleran, SF Lee
(2023)
A Comparative Study of High-Contrast Fluorescence Lifetime Probes for Imaging Amyloid in Tissue
F Gorka, CM Pearson, E Bulovaite, YP Zhang, A Handa, SGN Grant, TN Snaddon, LM Needham, SF Lee
Journal of Physical Chemistry B
(2021)
125

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