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  • Currently displaying 121 - 140 of 258 publications
Author(s)
Publication title
Journal Name
Publication year
Analysis of nanobody paratopes reveals greater diversity than classical antibodies
LS Mitchell, LJ Colwell
Protein engineering, design & selection : PEDS
(2018)
31
(doi: 10.1093/protein/gzy017)
FRET-enhanced photostability allows improved single-molecule tracking of proteins and protein complexes in live mammalian cells
S Basu, L-M Needham, D Lando, EJR Taylor, KJ Wohlfahrt, D Shah, W Boucher, YL Tan, LE Bates, O Tkachenko, J Cramard, BC Lagerholm, C Eggeling, B Hendrich, D Klenerman, SF Lee, ED Laue
Nature communications
(2018)
9
(doi: 10.1038/s41467-018-04486-0)
Single-Molecule Characterization of the Interactions between Extracellular Chaperones and Toxic α-Synuclein Oligomers
DR Whiten, D Cox, MH Horrocks, CG Taylor, S De, P Flagmeier, L Tosatto, JR Kumita, H Ecroyd, CM Dobson, D Klenerman, MR Wilson
Cell Reports
(2018)
23
(doi: 10.1016/j.celrep.2018.05.074)
α-synuclein oligomers interact with ATP synthase and open the permeability transition pore in Parkinson's disease
MHR Ludtmann, PR Angelova, MH Horrocks, ML Choi, M Rodrigues, AY Baev, AV Berezhnov, Z Yao, D Little, B Banushi, AS Al-Menhali, RT Ranasinghe, DR Whiten, R Yapom, KS Dolt, MJ Devine, P Gissen, T Kunath, M Jaganjac, EV Pavlov, D Klenerman, AY Abramov, S Gandhi
Nature Communications
(2018)
9
(doi: 10.1038/s41467-018-04422-2)
A sticky situation: Aberrant protein-protein interactions in Parkinson's disease
J Brown, MH Horrocks
Seminars in cell & developmental biology
(2018)
99
(doi: 10.1016/j.semcdb.2018.05.006)
Single-Molecule Light-Sheet Imaging of Suspended T Cells
A Ponjavic, J McColl, AR Carr, AM Santos, K Kulenkampff, A Lippert, SJ Davis, D Klenerman, SF Lee
Biophysical Journal
(2018)
114
(doi: 10.1016/j.bpj.2018.02.044)
Weighing one protein with light.
SF Lee, D Klenerman
Science
(2018)
360
(doi: 10.1126/science.aat5851)
FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions
S Qamar, G Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, EC Phillips, A Miyashita, D Williams, F Ströhl, W Meadows, R Ferry, VJ Dardov, GG Tartaglia, LA Farrer, GS Kaminski Schierle, CF Kaminski, CE Holt, PE Fraser, G Schmitt-Ulms, D Klenerman, T Knowles, M Vendruscolo, P St George-Hyslop
Cell
(2018)
173
(doi: 10.1016/j.cell.2018.03.056)
Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell.
D Lando, S Basu, TJ Stevens, A Riddell, KJ Wohlfahrt, Y Cao, W Boucher, M Leeb, LP Atkinson, SF Lee, B Hendrich, D Klenerman, ED Laue
Nature protocols
(2018)
13
(doi: 10.1038/nprot.2018.017)
Comparative analysis of nanobody sequence and structure data
LS Mitchell, LJ Colwell
Proteins
(2018)
86
(doi: 10.1002/prot.25497)
Elucidation of Excitation Energy Dependent Correlated Triplet Pair Formation Pathways in an Endothermic Singlet Fission System.
A Thampi, H Stern, A Cheminal, J Petty II, J Anthony, A Rao
J Am Chem Soc
(2018)
140
(doi: 10.1021/jacs.7b06274)
Correction to 'Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species'.
L-M Needham, J Weber, JWB Fyfe, OM Kabia, DT Do, E Klimont, Y Zhang, M Rodrigues, CM Dobson, S Gandhi, SE Bohndiek, TN Snaddon, SF Lee
Royal Society Open Science
(2018)
5
(doi: 10.1098/rsos.180308)
The small heat shock protein Hsp27 binds α-synuclein fibrils, preventing elongation and cytotoxicity
D Cox, DR Whiten, JWP Brown, MH Horrocks, R San Gil, CM Dobson, D Klenerman, AM van Oijen, H Ecroyd
Journal of Biological Chemistry
(2018)
293
(doi: 10.1074/jbc.m117.813865)
Optical Structural Analysis of Individual α‐Synuclein Oligomers
JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, SF Lee
Angewandte Chemie
(2018)
130
(doi: 10.1002/ange.201710779)
Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity
F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, SE Jackson, CM Dobson, D Klenerman
ACS chemical biology
(2018)
13
(doi: 10.1021/acschembio.7b01039)
Shedding light on aberrant interactions – a review of modern tools for studying protein aggregates
F Kundel, L Tosatto, DR Whiten, DC Wirthensohn, MH Horrocks, D Klenerman
FEBS Journal
(2018)
285
(doi: 10.1111/febs.14409)
Capturing resting T cells: the perils of PLL.
AM Santos, A Ponjavic, M Fritzsche, RA Fernandes, JB de la Serna, MJ Wilcock, F Schneider, I Urbančič, J McColl, C Anzilotti, KA Ganzinger, M Aßmann, D Depoil, RJ Cornall, ML Dustin, D Klenerman, SJ Davis, C Eggeling, SF Lee
Nat Immunol
(2018)
19
(doi: 10.1038/s41590-018-0048-8)
Maximizing the field of view and accuracy in 3D Single Molecule Localization Microscopy
SA Rehman, AR Carr, MO Lenz, SF Lee, K O'Holleran
Opt Express
(2018)
26
(doi: 10.1364/oe.26.004631)
Detecting RNA base methylations in single cells by in situ hybridization
RT Ranasinghe, MR Challand, KA Ganzinger, BW Lewis, C Softley, WH Schmied, MH Horrocks, N Shivji, JW Chin, J Spencer, D Klenerman
Nature Communications
(2018)
9
(doi: 10.1038/s41467-017-02714-7)
CLIC4 is regulated by RhoA-mDia2 signaling through Profilin-1 binding to modulate filopodium length
E Argenzio, KM Kedziora, L Nahidiazar, T Isogai, A Perrakis, K Jalink, WH Moolenaar, M Innocenti
(2018)
(doi: 10.1101/259259)
Yusuf Hamied Department of Chemistry
Lensfield Road
Cambridge
CB2 1EW
T: +44 (0) 1223 336300
enquiries@ch.cam.ac.uk
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