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Currently displaying 1 - 20 of 242 publications

α-Synuclein driven cell susceptibility in Parkinson’s disease

S Lee, J Breiter, J Beckwith, E Brock, J Lachica, C Toomey, B Fu, M Ryten, L Weiss, N Wood, S Gandhi, M Vendruscolo

(2025)

Large-scale visualisation of α-synuclein oligomers in Parkinson’s disease brain tissue

R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, JS Beckwith, R Tian, EE Brock, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, R Popovic, J Evans, Y Goh, B Kurt, L Senicar, M Edmonds, T Bartels, N Bengoa-Vergniory, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee

Nat Biomed Eng

(2025)

(doi: 10.1038/s41551-025-01496-4)

Nano-org, a functional resource for single-molecule localisation microscopy data

S Shirgill, DJ Nieves, JA Pike, MA Ahmed, H Abbott, MHH Baragilly, K Savoye, JD Worboys, KS Hazime, E Bruggeman, A Garcia, DJ Williamson, P Rubin-Delanchy, R Peters, DM Davis, R Henriques, SF Lee, DM Owen

Nat Commun

(2025)

8674

(doi: 10.1038/s41467-025-63674-x)

Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal.

MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl

(2025)

(doi: 10.1101/2025.09.08.674880)

Species-specific surface dwell times and accumulation of microbes investigated by holographic microscopy

EE Brock, SA Matthews, EJ Cohen, S Nakamura, LG Wilson

Philos Trans A Math Phys Eng Sci

(2025)

383

20240265

(doi: 10.1098/rsta.2024.0265)

Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease

JR Evans, M Grant-Peters, JS Beckwith, CE Toomey, R Popovic, JC Breiter, JW Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, EE Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, RS Saleeb, H Lucas-Clarke, A Penverne, K D’Sa, CW Pang, MH Horrocks, M Vendruscolo, N Wood, SF Lee, M Ryten, S Gandhi

(2025)

(doi: 10.1101/2025.08.25.671921)

α-Synuclein driven cell susceptibility in Parkinson’s disease

JC Breiter, JS Beckwith, EE Brock, J Lachica, CE Toomey, B Fu, M Ryten, LE Weiss, NW Wood, S Gandhi, M Vendruscolo, SF Lee

(2025)

(doi: 10.1101/2025.08.19.670819)

Patch deconvolution for Fourier light-field microscopy

B Fu, CL Jones, D Heraghty, S Yang, C O’Brien-Ball, V Junghans, H Yang, TPJ Knowles, LE Weiss, RA Fernandes, SF Lee

(2025)

(doi: 10.1101/2025.06.13.659385)

Volumetric single-molecule tracking inside subcellular structures

S Daly, JE Chambers, C Jones, B Fu, JD Manton, JS Beckwith, SJ Marciniak, DC Gershlick, SF Lee

(2025)

(doi: 10.1101/2025.06.09.658280)

Advanced image processing methods for 3D high-throughput microscopy

B Fu

(2025)

(doi: 10.17863/CAM.118852)

The Origin of Single-Molecule Sensitivity in Label-Free Solution-Phase Optical Microcavity Detection

CA Saavedra Salazar, D Sole-Barber, S Wan, JK Rasch, M Reitz, B Cullinane, N Asgari, L-M Needham, J Yuen-Zhou, RH Goldsmith

ACS nano

(2025)

6342

(doi: 10.1021/acsnano.4c16276)

3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain

S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O Holleran, SGN Grant, MH Horrocks, SF Lee

ACS Chemical Neuroscience

(2024)

(doi: 10.1021/acschemneuro.4c00684)

Vortex Light Field Microscopy: 3D spectral single-molecule imaging with a twist

B Zhang, S Daly, C Zhu, MO Lenz, LE Weiss, L-M Needham, R Peters, SF Lee, K O’Holleran

Optica

(2024)

1519

(doi: 10.1364/optica.534148)

3D super-resolution imaging of PSD95 reveals an abundance of diffuse protein supercomplexes in the mouse brain

S Daly, E Bulovaite, A Handa, K Morris, L Muresan, C Adams, T Kaizuka, A Kitching, A Spark, G Chant, K O’Holleran, SGN Grant, MH Horrocks, SF Lee

(2024)

(doi: 10.1101/2024.10.14.617231)

POLCAM: instant molecular orientation microscopy for the life sciences

E Bruggeman, O Zhang, L-M Needham, M Körbel, S Daly, M Cheetham, R Peters, T Wu, AS Klymchenko, SJ Davis, EK Paluch, D Klenerman, MD Lew, K O'Holleran, SF Lee

Nature methods

(2024)

1873

(doi: 10.1038/s41592-024-02382-8)

Evolution of a large periplasmic disk in Campylobacterota flagella enables both efficient motility and autoagglutination.

EJ Cohen, T Drobnič, DA Ribardo, A Yoshioka, T Umrekar, X Guo, J-J Fernandez, EE Brock, L Wilson, D Nakane, DR Hendrixson, M Beeby

Dev Cell

(2024)

3306

(doi: 10.1016/j.devcel.2024.09.008)

Single-Molecule Sensitivity in Hot Microcavities in the Unstable Regime

CA Saavedra Salazar, D Sole-Barber, N Asgari, B Cullinane, L-M Needham, J Rasch, M Reitz, S Wan, J Yuen-Zhou, R Goldsmith

(2024)

(doi: 10.26434/chemrxiv-2024-xgtxg)

Single-molecule digital sizing of proteins in solution

G Krainer, RPB Jacquat, MM Schneider, TJ Welsh, J Fan, QAE Peter, EA Andrzejewska, G Šneiderienė, MA Czekalska, H Ausserwoeger, L Chai, WE Arter, KL Saar, TW Herling, TM Franzmann, V Kosmoliaptsis, S Alberti, FU Hartl, SF Lee, TPJ Knowles

Nature Communications

(2024)

7740

(doi: 10.1038/s41467-024-50825-9)

Vortex light field microscopy: 3D spectral single-molecule imaging with a twist

B Zhang, S Daly, C Zhu, MO Lenz, LE Weiss, L-M Needham, R Peters, SF Lee, K O’Holleran

(2024)

(doi: 10.1101/2024.07.18.604091)

Advances in volumetric super-resolution microscopy and single-particle tracking

S Daly

(2024)

(doi: 10.17863/CAM.113698)

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