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Currently displaying 1 - 20 of 258 publications

BPS2026 – Single-molecule microfluidic diffusional sizing

JJ Fan, R Jacquat, G Krainer, TPJ Knowles, SF Lee

Biophysical Journal

(2026)

125

144a

(doi: 10.1016/j.bpj.2025.11.1026)

Patch deconvolution for Fourier light-field microscopy

B Fu, CL Jones, D Heraghty, S Yang, C O'Brien-Ball, V Junghans, H Yang, D Klenerman, TPJ Knowles, LE Weiss, RA Fernandes, SF Lee

Biophysical journal

(2026)

125

1305

(doi: 10.1016/j.bpj.2026.01.034)

Volumetric Single-Molecule Tracking Inside Subcellular Structures

S Daly, JE Chambers, C Jones, B Fu, JD Manton, JS Beckwith, SJ Marciniak, DC Gershlick, SF Lee

Small (Weinheim an der Bergstrasse, Germany)

(2026)

e09162

(doi: 10.1002/smll.202509162)

Protein-protein interactions drive differences in the spatiotemporal dynamics of transcription factors NANOG and SOX2 in naïve pluripotent cells

GG Agsu, Y Cao, D Jain, SE Strawbridge, S Daly, Z Zhang, A Wurmser, K Bowers, IO De Almeida, G Nikolenyi, S Berger, M Jonaitis, K Guma’a, T Pauzaite, S Maretvadakethope, L Bates, JA Nathan, BD Hendrich, R Perez-Carrasco, KJ Chalut, D Klenerman, TE Boroviak, SF Lee, D Holcman, S Basu

(2025)

(doi: 10.64898/2025.12.03.691924)

SMOLM-LFM: ratiometric single molecule orientation without polarizers

AG Vesga, L Aleman-Castaneda, HS Heil, S Daly, E Bruggeman, SF Lee, S Brasselet, R Henriques

(2025)

(doi: 10.1101/2025.11.26.690201)

Stress‐Induced Reorganization of Proteasomes Through Diffusion and Cytoskeleton‐Dependent Mechanisms

MJ Morten, Y Zhang, B Li, JX Meng, K Jiang, L Sirvio, J-E Lee, AH Lippert, M Burridge, KD Pulgar Prieto, AR Carr, A Ponjavic, SF Lee, D Finley, D Klenerman, Y Ye

Small (Weinheim an der Bergstrasse, Germany)

(2025)

e06260

(doi: 10.1002/smll.202506260)

Neurodegeneration emerges at a cellular tipping point between aggregate accumulation and removal.

MW Cotton, S Venkatesan, JS Beckwith, D Böken, CK Xu, E Fertan, JC Breiter, LE Berkowicz, LS Salazar, A Von Schulze, EA Andrzejewska, EE Brock, HL Han, MM Schneider, DD Sahtoe, D Baker, JB Rowe, A Goriely, WA McEwan, TPJ Knowles, SF Lee, R Halfmann, D Klenerman, G Meisl

(2025)

(doi: 10.1101/2025.09.08.674880)

α-Synuclein driven cell susceptibility in Parkinson’s disease

S Lee, J Breiter, J Beckwith, E Brock, J Lachica, C Toomey, B Fu, M Ryten, L Weiss, N Wood, S Gandhi, M Vendruscolo

(2025)

(doi: 10.21203/rs.3.rs-7375981/v1)

Nanoscale spatial-omics via contrastive embedding of single-molecule localisation data

S Shirgill, LG Jensen, DJ Nieves, MC Wales, A Kaminer, K Savoye, R Peters, M Heilemann, R Henriques, SF Lee, P Rubin-Delanchy, DM Owen

(2025)

(doi: 10.1101/2025.10.07.679170)

Large-scale visualisation of α-synuclein oligomers in Parkinson’s disease brain tissue

R Andrews, B Fu, CE Toomey, JC Breiter, J Lachica, JS Beckwith, R Tian, EE Brock, L-M Needham, GJ Chant, C Loiseau, A Deconfin, K Baspin, R Popovic, J Evans, Y Goh, B Kurt, L Senicar, M Edmonds, T Bartels, N Bengoa-Vergniory, PJ Magill, Z Jaunmuktane, OJ Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, NW Wood, LE Weiss, S Gandhi, SF Lee

Nature Biomedical Engineering

(2025)

(doi: 10.1038/s41551-025-01496-4)

Nano-org, a functional resource for single-molecule localisation microscopy data

S Shirgill, DJ Nieves, JA Pike, MA Ahmed, H Abbott, MHH Baragilly, K Savoye, JD Worboys, KS Hazime, E Bruggeman, A Garcia, DJ Williamson, P Rubin-Delanchy, R Peters, DM Davis, R Henriques, SF Lee, DM Owen

Nature Communications

(2025)

8674

(doi: 10.1038/s41467-025-63674-x)

Species-specific surface dwell times and accumulation of microbes investigated by holographic microscopy.

EE Brock, SA Matthews, EJ Cohen, S Nakamura, LG Wilson

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences

(2025)

383

20240265

(doi: 10.1098/rsta.2024.0265)

T-cell signaling relies on partial CD45-exclusion at sub-micron sized cellular contacts

M Kotowski, DF Heraghty, M Körbel, D Banik, Z Zhang, S Kedia, B Fu, J McColl, B Li, J Clarke, M Fellermeyer, Y Lui, G Bossi, DK Cole, H Chen, E Basiarz, S Sharma, E Petsalaki, CJ Tape, B de Wet, SF Lee, AM Santos, D Klenerman, SJ Davis

(2025)

(doi: 10.1101/2025.08.29.673015)

Microglial activation and alpha-synuclein oligomers drive the early inflammatory phase of Parkinson’s disease

JR Evans, M Grant-Peters, JS Beckwith, CE Toomey, R Popovic, JC Breiter, JW Brenton, A Fairbrother-Browne, S Strohbuecker, J Lachica, M Rodriguez-Lopez, EE Brock, B Fu, L Nahidiazar, P Lopez-Garcia, R Ferguson, RS Saleeb, H Lucas-Clarke, A Penverne, K D’Sa, CW Pang, MH Horrocks, M Vendruscolo, N Wood, SF Lee, M Ryten, S Gandhi

(2025)

(doi: 10.1101/2025.08.25.671921)