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Currently displaying 101 - 120 of 232 publications

Single-Molecule Light-Sheet Imaging of Suspended T Cells

A Ponjavic, J McColl, AR Carr, AM Santos, K Kulenkampff, A Lippert, SJ Davis, D Klenerman, SF Lee

Biophysical Journal

(2018)

114

2200

(doi: 10.1016/j.bpj.2018.02.044)

A sticky situation: Aberrant protein–protein interactions in Parkinson's disease

J Brown, MH Horrocks

Seminars in Cell and Developmental Biology

(2018)

(doi: 10.1016/j.semcdb.2018.05.006)

Weighing one protein with light

SF Lee, D Klenerman

Science

(2018)

360

378

(doi: 10.1126/science.aat5851)

Phase Separation of FUS is Modulated by Methylation State of Cation-π Interactions and Interaction with TNPO1

PH St George-Hyslop, S Qamar, G Wang, SJ Randle, FS Ruggeri, J Varela, CF Kaminski, GS Kaminski, M Vendruscolo, TPJ Knowles, D Klenerman, CE Holt, Q Lin, W meadows

Cell

(2018)

(doi: 10.1016/j.cell.2018.03.056)

Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell.

D Lando, S Basu, TJ Stevens, A Riddell, KJ Wohlfahrt, Y Cao, W Boucher, M Leeb, LP Atkinson, SF Lee, B Hendrich, D Klenerman, ED Laue

Nature Protocols

(2018)

1034

(doi: 10.1038/nprot.2018.017)

FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

S Qamar, G Wang, SJ Randle, FS Ruggeri, JA Varela, JQ Lin, EC Phillips, A Miyashita, D Williams, F Ströhl, W Meadows, R Ferry, VJ Dardov, GG Tartaglia, LA Farrer, GS Kaminski Schierle, CF Kaminski, CE Holt, PE Fraser, G Schmitt-Ulms, D Klenerman, T Knowles, M Vendruscolo, P St George-Hyslop

Cell

(2018)

173

720

(doi: 10.1016/j.cell.2018.03.056)

Comparative analysis of nanobody sequence and structure data.

LS Mitchell, LJ Colwell

Proteins: Structure, Function, and Bioinformatics

(2018)

697

(doi: 10.1002/prot.25497)

Elucidation of Excitation Energy Dependent Correlated Triplet Pair Formation Pathways in an Endothermic Singlet Fission System.

A Thampi, H Stern, A Cheminal, J Petty II, J Anthony, A Rao

J Am Chem Soc

(2018)

140

4613

(doi: 10.1021/jacs.7b06274)

Correction to 'Bifunctional fluorescent probes for detection of amyloid aggregates and reactive oxygen species'.

L-M Needham, J Weber, JWB Fyfe, OM Kabia, DT Do, E Klimont, Y Zhang, M Rodrigues, CM Dobson, S Gandhi, SE Bohndiek, TN Snaddon, SF Lee

Royal Society Open Science

(2018)

180308

(doi: 10.1098/rsos.180308)

The small heat shock protein Hsp27 binds -synuclein fibrils, preventing elongation and cytotoxicity

D Cox, DR Whiten, JWP Brown, MH Horrocks, R San Gil, CM Dobson, D Klenerman, AM van Oijen, H Ecroyd

J Biol Chem

(2018)

293

4486

(doi: 10.1074/jbc.M117.813865)

Optical Structural Analysis of Individual α‐Synuclein Oligomers

JA Varela, M Rodrigues, S De, P Flagmeier, S Gandhi, CM Dobson, D Klenerman, SF Lee

Angewandte Chemie

(2018)

130

4980

(doi: 10.1002/ange.201710779)

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity.

F Kundel, S De, P Flagmeier, MH Horrocks, M Kjaergaard, SL Shammas, SE Jackson, CM Dobson, D Klenerman

ACS Chemical Biology

(2018)

636

(doi: 10.1021/acschembio.7b01039)

Shedding light on aberrant interactions – a review of modern tools for studying protein aggregates

F Kundel, L Tosatto, DR Whiten, DC Wirthensohn, MH Horrocks, D Klenerman

FEBS Journal

(2018)

285

3604

(doi: 10.1111/febs.14409)

Capturing resting T cells: the perils of PLL

AM Santos, A Ponjavic, M Fritzsche, RA Fernandes, JB de la Serna, MJ Wilcock, F Schneider, I Urbančič, J McColl, C Anzilotti, KA Ganzinger, M Aßmann, D Depoil, RJ Cornall, ML Dustin, D Klenerman, SJ Davis, C Eggeling, SF Lee

Nature immunology

(2018)

203

(doi: 10.1038/s41590-018-0048-8)